This is an occasion on which we dedicate an important scientific facility at a university of global standing. Thirteen decades ago, a similar event occurred in Cambridge, when the Cavendish Laboratory was new. The history of the Cavendish and its leadership is a fascinating chronicle of the development of a university and the flowering of an age of science. That story will be used as the basis for considering some of the issues that will face Wisconsin and its science as the Shain Research Tower becomes an important new scientific locale and destination. The most important science done in the Cavendish was far from that imagined at its opening. In fact, the science of the Cavendish had been entirely reconceived just fifty years later. The same may be true of the science of the Shain. What are some of the possibilities?